In the process of foam flooding in heavy oil fields, the performance of single foaming agent is unstable. In view of this difficult problem, a new foaming agent system for foam flooding is designed in this paper. The foam synthesis index and temperature and salt resistance are taken as the evaluation indexes by Waring⁃Blender agitation method four kinds of foaming agents such as betaine, CTAB, SDBS and SDS were selected. The best foaming agents were betaine and CTAB. Through the experimental selection of different proportion of foaming single agent, the oil washing ability test and sand filling tube simulation experiment of CTAB and betaine system with 2∶1 ratio were carried out. The results show that the foaming agent system have good temperature and salt resistance and strong oil washing ability. In the sand⁃filled pipe simulation experiment, the two displacement modes of steam flooding plus foam flooding and steam foam alternating injection flooding are compared. The results show that the oil recovery can reach 60.7% by alternately injecting steam and foam fluid into the reservoir, which has certain reference value.